The anxiolytic effect of some plant extracts in clinical trials and animal models

Malkhaz Makashvili 1, *, Giorgi Andronikashvili 2, Tamila Bagashvili 2, Tea Gurashvili 2, Ketevan Gogeshvili 2, Tamar Nadiradze 3 and Nino Akhobadze 2

1 Faculty of Psychology, Ilia State University, Tbilisi, Georgia.
2 Department of Experimental Neurology, Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia.
3 Department of Science and Digital Technology, I.Gogebashvili University, Telavi, Georgia.
 
Review
World Journal of Biology Pharmacy and Health Sciences, 2021, 05(03), 038-043.
Article DOI: 10.30574/wjbphs.2021.5.3.0023
Publication history: 
Received on 02 February 2021; revised on 03 March 2021; accepted on 05 March 2021
 
Abstract: 
The phenomenon of  anxiety remains poorly understood and there is much to be learnt about  its’s effective treatment. Here we discuss the data of available scientific literature concerning the use of plant derived extracts in the treatment of anxiety. Study of the treating effects of natural alternatives to prescription drugs is very important in regard to limitations of current drug therapies. Significance of the study of treating efficacy of endemic plant species, endemic to Georgia in particular, and  the use of animal models, such as rat grooming and rat behavior in maze, for evaluation of the anxiolytic efficacy of phytomedicines is discussed as well. We conclude, that medical as well as experimental trials in animal models of anxiety provide strong argument for the use of  plant extracts as an alternative to the current drug therapies for anxiety.
 
Keywords: 
Anxiety; Treatment; Plant extracts; Animal models
 
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