Analysis of pathogenic bacteria and risk factors of neonatal ventilator-associated pneumonia

Objective: To study the pathogenic bacteria and risk factors of neonatal ventilator-associated pneumonia in order to provide a feasible basis for clinical intervention.
Methods: Selection object of study from our hospital in October 2019 to December 2020 neonatal intensive care unit 100 cases treated by mechanical ventilation more than 48 h of children, for all children with the summary of the clinical data, study the incidence of neonatal ventilator associated pneumonia, investigation of neonatal ventilator associated pneumonia pathogen at the same time,And summarize the related risk factors.
Results: Among the 100 children with mechanical ventilation for more than 48 hours, 20 (20.00%) of them developed ventilator-associated pneumonia.27 strains of pathogenic bacteria were isolated from 20 children. Through analysis and summary, it can be concluded that the pathogens of neonatal ventilator associated pneumonia were mainly Gram-negative bacteria, 19 strains in total, accounting for 70.37%. In addition, there were 7 strains of Gram-positive bacteria, accounting for 25.92%, and 1 strain of fungus, accounting for 3.70%.Klebsiella pneumoniae was the main gram-negative bacteria, with 14 strains, accounting for 51.85%.The risk factors of neonatal ventilator-associated pneumonia were summarized, which were mainly related to delivery mode, length of hospital stay, duration of mechanical ventilation, gestational age, birth weight, number of intubation, 1min Apgar score after birth, and the presence of primary pulmonary diseases. Logistic Regression analysis showed that Intubation more than 2 times was an independent risk factor for neonatal ventilator-associated pneumonia.0.05, the difference was statistically significant.
Conclusion: The pathogenic bacteria leading to ventilator associated pneumonia in newborn infants are mainly Gram-negative bacteria, and the main manifestation is Klebsiella pneumoniae. The risk factors leading to ventilator associated pneumonia in newborn infants are manifested in multiple aspects, which require clinical measures for comprehensive intervention, which can effectively ensure the safety of newborn infants.