1 Department of Pharmacognosy, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana-501506, India.
2 Department of Pharmaceutical Chemistry, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana-501506, India.
3 Department of Pharmaceutics, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana-501506, India.
4 Department of Pharmacology, Scient Institute of Pharmacy, Ibrahimpatnam, Hyderabad, Telangana-501506, India
Received on 15 November 2022; revised on 27 December 2022; accepted on 29 December 2022
The aim of the present study was to evaluate antidiabetic activity of ethanol extract of leaves of Flax plant (Linum usitatissimum) in streptozotocin (STZ) induced diabetic rats. Ethanol extract of leaves of Linum usitatissimum (EELL) or glibenclamide was administered to the rats orally daily for 28 days. Blood glucose levels at weekly interval and on 29th day, serum biochemical parameters were carried out to evaluate its antidiabetic effect in diabetic rats. Blood glucose, creatinine, BUN, AST and ALT levels were significantly increased in STZ induced diabetic rats as compared to vehicle control rats. After 28 days administration of EELL showed the significant decrease in above levels as compared to diabetic control rats. The study results suggest that the ethanol extract of leaves of Linum usitatissimum clearly demonstrated the antidiabetic activity in an experimental model of rats.
Linum usitatissimum; Glibenclamide; Streptozotocin; Diabetic rats
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S Neelufar Shama, C Sravanthi, D Pranitha, D Phaneendra Pavan, V Ravali and P Sravan Kumar. Antidiabetic activity of ethanol extract of leaves of flax plant (Linum usitatissimum L.). World Journal of Biology Pharmacy and Health Sciences, 2022, 12(03), 365-369. Article DOI: https://doi.org/10.30574/wjbphs.2022.12.3.0275