1 Department of Agronomy and Agri-Food, Engineering School of Agronomy and Environment, Higher Institute of Technology of Ambositra, BP 306, Madagascar.
2 Department of Pharmacology, Sciences Faculty, BP 906, University of Antananarivo, Madagascar.
3 Department of Chemistry, Sciences Faculty, BP 1246-301, University of Fianarantsoa, Madagascar.
4 School for International Training (SIT), Study Abroad Madagascar, Kipling Road, Brattleboro, Vermont 05302, USA.
Received on 17 November 2022; revised on 29 December 2022; accepted on 31 December 2022
Our objective was to study the activity of Ludwigia octovalvis hydro alcoholic extract in rats made experimentally hypertensive by a hypersodic diet. After 21 days of this diet, the systolic and diastolic blood pressure of these animals increases to 200.1 ± 1.5 / 155.6 ± 1.5 mm Hg, respectively. Administered orally, the extract reduces this high blood pressure. The control group blood pressure returned to its normal value (113.2 ± 1.2/76.3 ± 1) mm Hg after 24 days, versus 9th, 15th and 19th days for animals treated with the extract at doses of 400, 200 and 100 mg / kg (P <0.05). It does not have any diuretic activity but relaxes the isolated aorta contracted with norepinephrine 10-4 M with an EC50 equal to 1.18 ± 0.02 mg/ml. These results indicate that Ludwigia octovalvis extract has an antihypertensive activity by its vasodilator property. The polyphenols, triterpenoids and flavonoids in the extract may be responsible for its hypotensive activity.
Ludwigia octovalvis; Hypertension; High-salt diet; Vasodilator
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Kanto RATOVONARINDRA, Olivier RAKOTOARISON, Claudine Aimée RASOLOHERY, Nathaniel QUANSAH and Patricia RANDRIANAVONY. Antihypertensive activity of Lugwigia octovalvis (Jacq.) P. H. Raven (Onagraceae) hydro alcoholic extract on rat. World Journal of Biology Pharmacy and Health Sciences, 2023, 13(01), 014-019. Article DOI: https://doi.org/10.30574/wjbphs.2023.13.1.0287