Antihypertensive activity of Lycopodium cernuum (Lycopodiaceae) hydro alcoholic extract on rats
1 Department of Medicines Quality Control, Madagascar Medicines Agency, BP 8145, 101 Antananarivo, Madagascar.
2 Laboratory of Chemistry Applied to Natural Substances, Department of Chemistry, Sciences Faculty, BP 906, University of Antananarivo, Madagascar.
3 Department of Chemistry, China Pharmaceutical University, Nanjing 211198, PRC China.
4 Department of Pharmacy, China Pharmaceutical University, Nanjing 211198, PRC China.
5 Department of Promoting Biodiversity and health, Faculty of Science, Technology and the Environment, Road to Campus Ambondrona. Rue Georges V. University of Mahajanga, BP 652, Madagascar.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(02), 118–123.
Article DOI: 10.30574/wjbphs.2024.18.2.0245
Publication history:
Received on 19 March 2024; revised on 29 April 2024; accepted on 02 May 2024
Abstract:
The aim of this work was to study the antihypertensive activity of the hydroalcoholic extract of the aerial part of Lycpodium cernuum in rats made experimentally hypertensive with a hypersodic diet. Its hypotensive effect was studied in vivo and its vascular effect was studied in vitro on the isolated aorta.
The normal blood pressure of the rats was 103.83 ± 3.7 / 82.13 ± 2 mmHg (systole/diastole). After 21 days on the high-salt diet, their blood pressure rose to 208 ± 2.2 / 150.06 ± 2.5 mmHg. This pressure returned to normal after 22 days in the control lot compared to 6, 10 and 16 days in the animals treated with the extract at 400, 200 and 100 mg/kg of the extract orally administered. In vitro, the extract relaxes the isolated aorta contracted with norepinephrine 10-3 M with an EC50 equal to 0.65 ± 0.02 mg/ml. These results show that Lycopodium cernuum extract has an antihypertensive activity in rats by its vasodilatory effect. This activity could be due to the presence of phenolic compounds and/or alkaloids in the extract.
Keywords:
Antihypertensive; Rat; Lycopodium cernuum; Diet
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