Application of pharmacometric approaches in diabetes mellitus
Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamilnadu – 637205, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(03), 453–457.
Article DOI: 10.30574/wjbphs.2024.19.3.0645
Publication history:
Received on 29 July 2024; revised on 16 September 2024; accepted on 19 September 2024
Abstract:
Pharmacometrics is a scientific field which employs statistical and mathematical techniques to analyse, comprehend, and estimate a drug's pharmacokinetics and pharmacodynamics (PKPD). It facilitates data-driven decision-making in pharmacotherapy and drug development by quantifying uncertainty associated with drug behaviour. Pharmacometrics modelling has become an essential tool in the setting of diabetes, especially type 2 diabetes mellitus (T2DM), for comprehending the course of the disease and the consequences of treatment. This method focusses into the pharmacokinetics in various diabetic therapies, dose-response relationships, and the dynamics of insulin and glucose. Pharmacometrics improves clinical decision-making by offering insights into the complex problems linked to diabetes through the integration of many models. Beyond standard evaluation techniques, the use of pharmacometric models increases the statistical power for identifying pharmacological effects. This study emphasises the role that pharmacometrics plays in modelling the course of diabetes and the relationship between insulin and glucose, with the ultimate goal of optimising treatment approaches and enhancing patient outcomes.
Keywords:
Pharmacometric; Diabetes; Pharmacokinetics; Pharmacodynamics.
Full text article in PDF:
Copyright information:
Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0