Aquaporins: Navigating the channels of cellular hydration
1 Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.
2 B Pharmacy IV year, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(01), 175–181.
Article DOI: 10.30574/wjbphs.2024.18.1.0153
Publication history:
Received on 24 February 2024; revised on 07 April 2024; accepted on 09 April 2024
Abstract:
Aquaporin’s are water channel proteins found in all plasma membrane of various cells in all forms of life from bacteria to mammals. Around 17 mammalian aquaporin’s have been identified till date, which are classified into 3 subcategories based on their permeability. In normal physiology, AQPs serve as essential modulators of fluid transport and homeostasis in multiple organs and tissues. Altered expression of aquaporin’s is linked to numerous pathologies including fluid dysregulation, tumor metastasis and traumatic injury. Although some potential AQP modulators have been identified, challenges associated with the development of better modulators, include the suitability of the assay methods used to identify modulators and the drug ability of the target. The present review focus on aquaporin types and their altered conditions along with role of aquaporin’s in cancer and other diseases.
Keywords:
Water channel proteins; Aquaporin’s; Traumatic injury; Cancer
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