Barrier-protective properties of pterostilbene against LPS-induced sepsis
1 Department of Applied Biology, University of Labé, P.O Box 210, Republic of Guinea.
2 School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang 212013, China.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 16(01), 060–066.
Article DOI: 10.30574/wjbphs.2023.16.1.0403
Publication history:
Received on 17 August 2023; revised on 01 October 2023; accepted on 03 October 2023
Abstract:
Background: Sepsis is a major clinical problem and the leading cause of death in patients in intensive care units worldwide.
Objective: The present study aimed to explore whether pterostilbene (PTS) could protect mice against experimental endotoxemia.
Methodology: Forty-eight mice were randomly divided into 4 groups and challenged with LPS. Mouse mortality was observed twice daily for 7 days and survival rates were reported. Mice were randomly treated with pterostilbene or vehicle intraperitoneally (i.p.). One hour later, the animals were exposed to LPS (20 mg/kg). Cytokine responses were then assessed in serum isolated from blood collected after LPS administration to the mice.
Results: The results showed that pterostilbene significantly reduced mouse body weight loss and attenuated inflammatory responses by inhibiting TNF-α, IL-6 and IL-1β production in mice exposed to LPS.
Conclusion: This study highlights the role of pterostilbene in the pathogenesis of LPS-induced sepsis and its potential in the treatment of patients with sepsis.
Keywords:
Sepsis; Inflammatory Responses; Pterostilbene; Mice
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