Brain metastasis from endometrial cancer treated by surgery and stereotaxic radiotherapy on the operating bed: A case report and review of the literature

The occurrence of brain metastases from endometrial cancer is a rare phenomenon. Despite the poor prognosis of this presentation, offering the patient curative ablative treatment, when possible, improves significantly the prognosis and quality of life.
We report in this work the case of a 61-year-old female patient, treated in 2024 for endometrial cancer initially considered to be endometrioid type classified at stage II according to the FIGO 2023 classification, with a grade 3 and presence of vascular emboli. 8 months after her diagnosis, she developed an isolated brain metastasis, without other secondary distant locations. The revelation of this metastasis made it possible to adjust the initial histological diagnosis of endometrial cancer to carcinosarcoma. Our patient was treated by total surgical excision followed by stereotaxic irradiation of the surgical bed at a dose of 27 GY in 3 fractions, with good clinical tolerance. A summary of previous studies and recommendations on the treatment of brain metastases from endometrial cancer was presented.