A case report on Sjogren syndrome with autoimmune liver disorder

Ranjana S R 1, Sreelekshmy B S 1, Shaiju S Dharan 2 and Drishya L 2, *

1 Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, India.
2 Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, India.
 
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(01), 271–273.
Article DOI: 10.30574/wjbphs.2024.18.1.0193
Publication history: 
Received on 29 February 2024; revised on 13 April 2024; accepted on 16 April 2024
 
Abstract: 
Background: Primary Sjogren’s syndrome (pSS) is a chronic systemic and autoimmune disorder characterized by inflammation and dysfunction of exocrine glands. Liver involvement was the first extraglandular manifestations to be reported in patients with pSS. Tubulointerstitial nephritis (TIN) is the main renal involvement associated with pSS and manifest as distal renal tubular acidosis (RTA), and others, of which RTA is the main clinical presentation. RTA has been reported in 4.3 to 9% of pSS patients. In this case, patient experiences RTA.
Case Presentation: A 19 year old female patient was presented with complaints of abdominal pain, fatigue for 2 months and loose stools. She had history of autoimmune hepatitis and decompensated liver cirrhosis with portal hypertension (autoimmune), bilateral peroneal axonal neuropathy, grade II hepatic encephalopathy resolved and recurrent pustular lesion for past 2 years which rupture spontaneously and heals with scary. She also presented with recurrent hypokalemia which was corrected. No history of similar complaints among the family members.
Conclusion: This case explains the autoimmune liver disorder with newly diagnosed primary sjogren’s syndrome associated with recurrent hypokalemia.
 
Keywords: 
Sjogren’s syndrome; Autoimmune liver cirrhosis; Distal RTA; Hypokalemia; Peroneal neuropathy
 
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