Change of α - tocopherol, cholesterol, retinol and some fatty acids in pancreatic tissue of uncontrolled diabetic rats supported by resveratrol, lipoic acid and vitamin C
1 Biology Department, Faculty of Science, Adiyaman University, Adiyaman/Turkey.
2 Biology Department, Faculty of Science, Fırat University, Elazıg/Turkey.
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(03), 575–581.
Article DOI: 10.30574/wjbphs.2024.19.3.0679
Publication history:
Received on 15 August 2024; revised on 25 September 2024; accepted on 27 September 2024
Abstract:
In this study, the effects of resveratrol, lipoic acid and vitamin C on some biochemical changes in the pancreas tissue of rats treated with streptozotocin (STZ) type 1 diabetes were investigated. Resveratrol (R), Lipoic acid (LP), and Vitamin C (VC) were administered intraperitoneally to diabetic -1 rats without insulin. According to our findings, it was observed that the α-Tocopherol amount decreased in diabetes and diabetes + antioxidant groups when compared with the control group (p <0.01). Cholesterol levels did not differ between the groups. Palmitic acid (16: 0), palmitoleic acid (16: 1 n-7) and oleic acid (18: 1 n-9) in fatty acid composition decreased in diabetes and diabetes + antioxidant groups compared to control group. (p <0.05, p <0.01). Stearic acid (18: 0) was higher in diabetic groups than the control group. Linoleic acid (18: 2 n-6), Gamma-linolenic acid (18: 3 n-6), Arachidonic acid (20: 4 n-6) and docosahexaenoic acid (22: 6 n-3) were higher in diabetic groups (p <0.05, p <0.01). According to the results obtained, the antioxidant substances applied without insulin were insufficient in the tissues of rats with Type-1 diabetes requiring absolute insulin treatment. Also, the damaging effect of stz on the pancreas is observed when vitamin E levels decrease. Because vitamin E is an antioxidant substance that breaks down especially in the cell membrane and chain reaction in free radical reactions. The decrease in vitamin E levels can be explained by the increase in free radical levels in the tissue.
Keywords:
Diabetes; Pancreas; α - Tocopherol; Cholesterol; Fatty Acids; Lipoic Acid; Resveratrol; Vitamin C
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