Correlation of gut-gammaproteobacteria with body mass index and glycated haemoglobin in type-2 diabetes mellitus individuals in Nigeria

The aim of the study is to correlate the gut-grammaproteobacteria with body mass index and glycated haemoglobin in Type-2 diabetes mellitus individuals.
Methods: The gut microbiota signature of 110 adults was studied using 16S rRNA sequencing targeting V3–V4 hypervariable regions and obtained data using Pearson correlation analyzed with Statistical Package for the Social Science (SPSS version 26).
Results: It was observed that the relative abundance of Class Bacteroidia and Gammaproteobacteria were positively correlated with Body mass index as follows: Bacteroidia versus BMI( p>0.005); Gammaproteobacteria versus BMI (r=0.464,p=0.045*), whereas that of Clostridia versus BMI(p>0.005); Actinobacteria versus BMI (p>0.005); Betaproteobacteria versus BMI (p>0.005); Sphingobacteriia versus BMI (p>0.005) and Alphaproteinobacteria versus BMI ( p>0.005) demonstrated a negative correlation. This study also observed that the relative abundance of Clostridia versus Hb1Ac (p>0.005), and Gammaproteobacteria versus Hb1Ac (p>0.005) were positively correlated, whereas Bacteroidia versus Hb1Ac (p>0.005); Actinobacteria versus HbA1C (p>0.005); Betaproteobacteria versus Hb1Ac (p>0.005); Sphingobacteriia versus Hb1Ac (p>0.005) and Alphaproteoobacteria (p>0.005) demonstrated a negative correlation.
Conclusion: These results suggested that gut-gammaproteobacteria significantly increased in obese subjects. The highest trend was correlated with Type-2 diabetes related obese subjects. The low microbial diversity and depletion of some of  specific taxa predisposed this T2D cohorts to gut dysbiosis.