Development and characterization of Decitabine Niosomes
Department of Pharmaceutics, Dhanvanthri College of Pharmaceutical Sciences, Thirumala Hills, Centre City, Appannapally, Mahabubnagar, Telangana 509001, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(01), 382–392.
Article DOI: 10.30574/wjbphs.2024.19.1.0445
Publication history:
Received on 12 June 2024; revised on 22 July 2024; accepted on 24 July 2024
Abstract:
The present study was focused on formulating and evaluating Decitabine containing niosomes formulation for In Vitro studies. Niosomal formulations were prepared by using different ratio of surfactant (Tween 80 and Tween 20) and cholesterol by thin film hydration method and were evaluated for In Vitro characteristics, stability studies. Span 20 containing niosomal formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that niosomal formulation was spherical in shape. Niosomes containing Tween 20 displayed higher percentage of drug release after 8 h as compared to other formulations. F-7 formulation was found to be stable at the end of the study on storage condition. The present study suggested that niosomal formulations provide sustained and prolonged delivery of drug with enhance bioavailability.
Keywords:
Niosomes; Decitabine; Bioavailability; Thin Film Hydration Technique; In Vitro Drug Release Studies
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