Development and evaluation of nanosuspension of famciclovir for ophthalmic application

Different excipients are used in formulation like Poloxamer-188, PVP K-90, different concentrations. F5 batch has shown the better results in high-speed homogenization Different excipients were shown variation in particle size, DSC study, drug content, entrapment efficiency and in-vitro dissolution study. Optimized formulation was chosen on the basis of results obtained from particle size and entrapment efficiency. The combination of excipients yields nanosuspension with the smallest average particle size and by the transformation of the nanosuspension into the physical stability of this system could be further enhanced.