Development and evaluation of pulsatile drug delivery system of Telmisartan

The aim of the present study was the formulation of pulsatile tablets of Telmisartan by press coating technique that could release the drug time controlled manner. The core tablets and press coated pulsatile tablet of Telmisartan was prepared by direct compression technique. The core tablets were formulated using super disintegrating agent cross carmilose sodium and pulsatile tablets were by using polymer HPMC and Ethyl cellulose in various concentrations. Compatibility studies indicate that there is no interaction between the excipient and the drug. All tablets formulations were subjected to evaluation parameter. All the parameters were found within the limit. Pulsatile tablets formulation F3, F4 and F5 showed sufficient lag time of 4hr, 3hr and 4 hr respectively. The optimized formulation of F3 was consider as the best formulation with respect to drug content, hardness, lag time and In vitro drug release. Formulation F3 showed optimum lag time of 4 hour and release maximum drug in 8 hour. The developed formulation was found to be stable during the stability studies of 3 month indicating good stability of the tablets.