Development and in vitro characterization of the proliposome gel of terbinafine hydrochloride

The study was conducted to prepare the Proliposome Gel of Terbinafine Hydrochloride to improve the drug loading and to sustain the drug release of terbinafine hydrochloride. Proliposome gel of terbinafine hydrochloride were prepared by modified coacervation phase separation method by varying the concentrations of PC to cholesterol. The prepared proliposome gel was evaluated for its pH, viscosity, drug loading, and In vitro drug release studies. The appearance, particle size and drug entrapment of each produced formulation was also evaluated. All proliposome gel formulation made were consistent, homogenous, and white creamy gel.