Development and In-Vitro characterization of risperidone loaded hydroxy propyl beta cyclodextrin nanosponge for enhancing bioavailability
Department of pharmaceutics, Faculty of pharmacy, Daksh Institute of Pharmaceutical Science, Chhatarpur, M.P, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(03), 139–151.
Article DOI: 10.30574/wjbphs.2023.15.3.0382
Publication history:
Received on 01 August 2023; revised on 19 September 2023; accepted on 22 September 2023
Abstract:
The purpose of the study was to develop and evaluate risperidone loaded nanosponge having prolonged residence time and sustained drug release. Nanosponges were prepared by emulsification solvent evaporation technique using cyclodextrins polymers in varying ratios. The nanosponges were evaluated for its percentage yield, drug entrapment efficiency, particle size and shape and In vitro drug release studies. The FTIR studies revealed uniform caging of the drug into the beta cyclodextrin cavity. The cyclodextrin based nanosponge showed particle size, drug entrapment efficiency and yield in the ranges of 148 - 164μm, 68.0 - 85.0% and 67.52 - 87.25% respectively. In vitro drug release confirms that formulation F2 was the best formulation as it was discovered that the nanosponge formulation's % release was 98.17±0.31% for 60 mins. This confirms the developed nanosponges are promising and have better bioavailability.
Keywords:
Nanosponges; Risperidone; Cyclodextrin; Novel drug delivery system
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