Development and In vitro characterization of submicron emulsion gel of Tenoxicam
Department of pharmaceutics, Faculty of pharmacy, Daksh Institute of Pharmaceutical Science, Chhatarpur, M.P, India.
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(03), 089–101
Article DOI: 10.30574/wjbphs.2023.15.3.0395
Publication history:
Received on 08 August 2023; revised on 16 September 2023; accepted on 19 September 2023
Abstract:
The study was conducted to prepare the submicron emulsion gel of tenoxicam to improve the drug loading and permeation of the drug through the skin. The emulsion was prepared using hot homogenization and ultrasonification method. Further sonification was done to obtain the desired size of emulsion. Then by adjusting the concentration of carbopol 947 as 1%, 1.5%, and 2%, the gel was produced from prepared emulsion. The prepared emulgel was evaluated for its pH, viscosity, drug loading, and In vitro drug release studies. The appearance, phase separation, drug entrapment, and globule size of each produced formulation was also evaluated. All submicron emulsion made were consistent, homogenous, and free from phase separation and drug precipitation.
Keywords:
Submicron emulgel; Tenoxicam; Novel drug delivery system; Hydrophobic drugs
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0