Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats
1 Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku, Awka. Anambra State. Nigeria.
2 Department of Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli campus. Anambra State. Nigeria.
3 Department of General Medicine, Faculty of Clinical Medicine, Royal Bournemouth Hospital (University Hospital Dorset NHS Foundation Trust) Bournemouth, England, BH7 7DW United Kingdom.
4 Department of Gastroenterology, Faculty of Clinical Medicine, Royal Bournemouth Hospital (University Hospital Dorset NHS Foundation Trust) Bournemouth, England, BH7 7DW United Kingdom.
5 Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Abia StateUniversity Teaching Hospital, Aba. Abia State. Nigeria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(02), 041–048.
Article DOI: 10.30574/wjbphs.2024.18.2.0236
Publication history:
Received on 17 March 2024; revised on 28 April 2024; accepted on 01 May 2024
Abstract:
The effects of methanol stem bark extract of Ochna schweinfurthiana were studied using Wistar rats. Twenty (20) experimental animals (Wistar rats) were randomly grouped into four groups of 5 rats each. They were allowed to acclimatize for 2 weeks. Rats in group A served as the control and were fed with rat feed and water only, rats in groups B to D were fed with normal rat feed, water and were fed with different doses of Ochna schweinfuthiana extracts at 200, 400 and 800mg/kg respectively for 4 weeks. The Animals were sacrificed under anesthesia after the experiment and liver was harvested and the weights were taken. Blood samples were collected for liver enzymes estimation: aspartate transaminase (AST), alkaline phosphate (ALP) and alanine transaminase (ALT) were checked. The extract proved to be hepato-protective as there were significant decrease in the liver function enzymes (AST, ALT, and ALP) P<0.05. This may indicate some hepato-protective effect of Ochna schweinfurthiana.
Keywords:
AST; ALP; ALT; Ochna schweinfurthiana; Wistar rats
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