Effects of samin yogurt on the liver of adult wistar rats
1 Department of Anatomy and Neurobiology, Faculty of Basic Medical Sciences, Imo State University, Owerri, Nigeria.
2 Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra state, Nigeria.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2021, 06(01), 049-053.
Article DOI: 10.30574/wjbphs.2021.6.1.0036
Publication history:
Received on 13 March 2021; revised on 18 April 2021; accepted on 21 April 2021
Abstract:
Background: Yogurt is basically fermented milk that is heated and mixed with two types of body friendly bacteria. It is very nutritious and therefore, it is being eaten by all and sundry.
Purpose: The study was designed to determine the effect of yogurt on the liver of adult Wister rats.
Method: A total of twenty four adzult Wister rats bred and harboured at the animal house of Anatomy and Neurobiology department, Imo State University Owerri were used for the study. The rats which weighed between 180 and 220 grammes were separated and housed in four different cages marked A, B, C and D. Each cage contained four rats. The group A served as control group and so received only the normal rat feed and water. Group B rats were administered 2500mg/kg body weight of yogurt; group C received 5000mg/kg body weight of yogurt why group D was given 10000mg/kg body weight of yogurt, all through oral intubation for four weeks. At the end of the four week treatment, the rats were anesthetized in chloroform vapour and the liver was dissected out for histological investigations.
Results: On examining the processed liver tissue, it was observed that there was a mild (for group B), moderate (for group C), and serve (for group D) lymphocyte infiltration on the liver portal tract when compared to the control group which showed very little presence of haepatocytes around a central venule. The effect observed could be described to be dose dependent.
Keywords:
Haepatocytes; Liver; lymphocytes; Wister rats; Samin Yogurt
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