Evaluation of anti-hypertensive and vasorelaxant activity of ethanolic extract of Passiflora edulis (Passifloraceae) Leaves in rat
1 Laboratory of Biotechnology Research Environment and Health, Doctoral School of Engineering Living and Modeling, Faculty of Sciences Technology and Environment, University of Mahajanga, Madagascar.
2 Department of Pharmacology, Sciences Faculty, BP 906, University of Antananarivo, Madagascar.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(03), 390-395.
Article DOI: 10.30574/wjbphs.2024.20.3.0944
Publication history:
Received on 18 October 2024; revised on 26 November 2024; accepted on 29 November 2024
Abstract:
Despite the great development in the field of medicine, medicinal plants are still used in Madagascar for primary health care and claimed to be efficient. This work aimed to evaluate Passiflora edulis leaves ethanolic extract effect on sodium enriched diet induced hypertension in rat. After 21 days of hyper sodium diet the blood pressure increases from 118.56 ± 2.18 / 70.31 ± 1 mmHg (PAS/PAD) to 210.50 ± 2.96/ 145.88 ± 1.20 mmHg. Administered orally at doses 75, 150 and 300 mg/kg, once a day, the extract decreases the blood pressure to its normal value within 8, 6 and 4 days, versus 10 days in control group. It increases 24 h urinary volume from 3.3 ± 0.20 ml in the control animals, to 4.56 ± 0.34, 5.7 ± 0.10 and 7.96 ± 0.37 ml (p<0.05). It also relaxes the isolated aorta contracted with noradrenaline at 10-3M, with EC50 equal to 1.84 ± 0.03 mg/ml. These results show the anti-hypertensive effect of Passiflora edulis ethanolic extract, which is probably associated with its diuretic and vasorelaxation activities.
Keywords:
Antihypertension; Diuretic; Passiflora edulis; Vasodilation
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