Evaluation of antimicrobial efficacy of flavonoids of Mimusops elengi L.
Department of Botany; S.S Jain Subodh Girls P.G. College, Jaipur, Rajasthan, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023., 13(01), 352-356.
Article DOI: 10.30574/wjbphs.2023.13.1.0035
Publication history:
Received on 06 December 2022; revised on 20 January 2023; accepted on 22 January 2023
Abstract:
Objective: The antimicrobial activity was evaluated using flavonoid extract of leaf; stem; bark and fruit of Mimusops elengi L.
Methodology: The flavonoids were extracted using cold extraction method. Antimicrobial activity of free and bound flavonoid extract was evaluated by disc diffusion assay against bacterial strains viz. Escherichia coli; Bacillus subtilis; Pseudomonas putida. Minimum inhibitory concentration (MIC) of the extract was evaluated through micro broth dilution method.
Results: Free flavonoid plant part extract of M. elengi L. exhibited significant activity against Escherichia coli; Bacillus subtilis and show no activity against Pseudomonas putida. Free flavonoid extract of bark of plant showed maximum inhibitory activity (DIZ = 14.0 + 1.00 mm) at 50mg/ml against Escherichia coli with MIC of 12.5 mg/ml. Bound flavonoid plant part extract of M. elengi L. exhibited significant activity against Escherichia coli; Pseudomonas putida with no activity against Bacillus subtilis. Bound flavonoid extracts of leaf significantly showed maximum antibacterial activity (DIZ =21.0 + 1.00 mm) at 50mg/ml against Escherichia coli with MIC of 6.25 mg/ml. Bound flavonoid extracts of bark also showed maximum antibacterial activity (DIZ =19.33 + 1.15 mm) at 50mg/ml against Pseudomonas putida with MIC of 6.25 mg/ml.
Conclusion: Results obtained advocates that use of plant parts especially leaf and bark of the selected plant could be used as natural antimicrobial agent against tested microorganism and upcoming resistant pathogens.
Keywords:
Mimusops elengi L.; Flavonoids; Escherichia coli; Bacillus subtilis; Pseudomonas putida
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