Formulation and evaluation of biodegradable floating drug delivery for solubility enhancement of diclofenac sodium
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(01), 103-110.
Article DOI: 10.30574/wjbphs.2023.13.1.0246
Publication history:
Received on 02 November 2022; revised on 29 December 2022; accepted on 31 December 2022
Abstract:
This learning's objective is to determine and investigate how pharmaceutical restrictions affect the characteristics of gastric floating tablets using diclofenac sodium (DICL) as a model for the solubility enhancement, sodium-bicarbonate (NaHCO3) or calcium-carbonate (CaCO3). Hydroxypropyl Methylcellulose (HPMC) as swelling polymer K100M or K15M is a gas-forming substance. BY direct-compression manufacturing is used to create floating DICL tablets. The tablet characteristics, swelling index, and in vitro resistance of compressed tablets were assessed. Under non-reducing circumstances, in vitro release was identified. Molecular interactions have been investigated using Fourier transform infrared spectroscopy and differential scanning calorimetry.
Keywords:
Diclofenac sodium; Floating tablets; Gastric Residence Time (GRT); Gastro retentive
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