Formulation and evaluation of Ebastine transferosomes
Department of Pharmaceutics, Dhanvanthri College of Pharmaceutical Sciences, Thirumala Hills, Centre City, Appannapally, Mahabubnagar, Telangana 509001, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(01), 393–400.
Article DOI: 10.30574/wjbphs.2024.19.1.0446
Publication history:
Received on 12 June 2024; revised on 22 July 2024; accepted on 24 July 2024
Abstract:
The present study was focused on formulating and evaluating Ebastine containing Transferosomes formulation for in vitro studies. Transferosomes formulations were prepared by using cold method and were evaluated for in vitro characteristics, stability studies. Transferosomes formulation displayed highest entrapment efficiency with desired particle size. SEM analyses showed that Transferosomes formulation was spherical in shape. Transferosomes containing lipid higher percentage of drug release after 8 h as compared to other formulations. F-2 formulation was found to be stable at the end of the study on storage condition. The present study suggested that Transferosomes gel formulations provide sustained and prolonged delivery of drug with enhance bioavailability.
Keywords:
Transferosomes; Ebastine; Bioavailability; Reverse Phase Evaporation; In Vitro Drug Release Studies
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