Formulation and evaluation of sustained release matrix tablet of ketoprofen

The aim of the study was the formulation of the sustained release matrix tablet of Ketoprofen. The sustained release tablet was prepared by wet-granulation method. The tablets were formulated using hydrophilic polymer HPMC K4M and xanthan gum. Preformulation compatibility studies indicate that there is no interaction between the excipient and the drug. Total seven batches were prepared and powder blends before compression was subjected for evaluation of flow properties. All the parameter was found to be within the limit showing good flow property. After compression, the entire tablet batch was evaluated for thickness, hardness, friability, weight variation, drug content uniformity, swelling index, In-vitro release pattern. The thickness of tablet indicates that die fill was uniform in all the formulation and the formulation possessed sufficient hardness & friability indicating a good mechanical strength of the development formulation. The weight of the all the formulation were found to be with in pharmacopeial limit. The In-Vitro dissolution profile of all the formulation of Ketoprofen was controlled over an extended period of time. The optimized formulation of F7 containing combination of HPMC K4M and xanthan gum was consider as the best formulation with respect to its sustained in vitro drug release for 12 hrs, total sustained release time & improved bioavailability. The developed formulation was found to be stable during the stability studies of 3 month indicating good stability of the tablets.