Formulation and evaluation of valsartan solid dispersion for improvement of dissolution profile
1 Lecturer, Department of pharmacy, Elixir Institute of Pharmacy, Purandar- 412301, Pune, Maharashtra, India.
2 Principal, Department of pharmacy, Elixir Institute of Pharmacy, Purandar-412301, Pune, Maharashtra, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(02), 208–224.
Article DOI: 10.30574/wjbphs.2023.15.2.0314
Publication history:
Received on 07 June 2023; revised on 17 July 2023; accepted on 20 July 2023
Abstract:
In terms of physicochemical factors, solubility is the most crucial to medication absorption and therapeutic efficacy. Bioavailability is low because the medicine is poorly soluble in water and is absorbed poorly in aqueous GIT fluid. In this research, a solid dispersion version of the hypertension drug valsartan was developed to improve its bioavailability and blood pressure-lowering effects. The solubility of Valsartan is improved by using the solid dispersion (kneading method) technique using Soluplus as a carrier (also act as taste masking agent). They were distinguished from one another based on studies examining solubility, in vitro dissolution, dissolving efficiency, and stability. X-ray diffraction, FT-IR spectroscopy, and differential scanning Calorimetry were used to investigate the solid state properties of dispersions (XRD). A 1:1 medication-to-polymer solid dispersion showed 97.77% drug release after 30 minutes. FTIR, DSC, and XRD analyses of solid dispersions all corroborated their formation. A DSC study shown that under accelerated climate settings, kneaded solid dispersion remained stable for 30 days longer than other solid dispersions.
Keywords:
Valsartan; Soluplus; Solid dispersion; Kneading; Dissolution
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