Formulation and In vitro characterization of the sustained release liposphere containing flavonoid Naringin
Department of pharmaceutics, Faculty of pharmacy, Daksh Institute of Pharmaceutical Science, Chhatarpur, M.P, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(03), 166–177
Article DOI: 10.30574/wjbphs.2023.15.3.0396
Publication history:
Received on 08 August 2023; revised on 22 September 2023; accepted on 25 September 2023.
Abstract:
The purpose of the study was to formulate sustained release liposphere of naringin. The aim was to increase the solubility and improve the loading of drug as well as drug rlease. The liposphere was formulated using melt dispersion method and then sonicated to achieve the desired size. The formulated liposphere were then evaluated for drug loading, entrapment of drug, solubility and In vitro drug release studies. The highest percentages of drug loading and drug entrapment are seen observed to be 16.233±0.208% and 97.395±0.189%. The manufactured liposphere of naringin showed sustained release to be greater than 96.397±0.124% within 12 hours.
Keywords:
Liposphere; Naringin; Novel drug delivery system; Sustained release; Flavonoid; Encapsulation
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