Formulation & development of fast dissolving film of Resperidone
1 Department of Quality Assurance, H.L.M.C. College of Pharmacy, Faizpur, Maharashtra, India.
2 Department of Pharmacology, H.L.M.C. College of Pharmacy, Faizpur, Maharashtra, India.
3 Department of Quality Assurance, H.L.M.C. College of Pharmacy, Faizpur, Maharashtra, India.
4 Department of Pharmacognosy, H.L.M.C. College of Pharmacy, Faizpur, Maharashtra, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(03), 132–140.
Article DOI: 10.30574/wjbphs.2023.13.3.0120
Publication history:
Received on 07 January 2023; revised on 10 March 2023; accepted on 12 March 2023
Abstract:
Risperidone, an Antipsychotic drugs. Risperidone undergoes first pass metabolism on oral administration resulting in reduced bioavailability (60%). Thus the objective of the present study was to formulate and evaluate Fast Dissolving Film of Risperidone to overcome the limitation of bioavailability and increase patient’s compliance. In the present study Fast Dissolving Film were prepared by solvent-casting method using hydrophilic polymer HPMC K4M and PEG 400 as plasticizer. The eighteen formulations were prepared by the application of heat drying technique and evaluated for the fast dissolving films specification and characteristics. It was found that, the films has potential to modify drug release rate and possess good stability and less fragile property. The F9 batch of dried Fast Dissolving Film has shown promising drug release within 10 min (95.11%) and tensile strength.
Keywords:
Risperidone; Fast Dissolving Film; Solvent Casting Method; Orodispersible; HPMC K4M
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