Hyperthermia
Department of Pharmacology, NRI College of Pharmacy, Vijayawada, Andhra Pradesh, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2023., 13(01), 357-361.
Article DOI: 10.30574/wjbphs.2023.13.1.0012
Publication history:
Received on 27 November 2022; revised on 08 January 2023; accepted on 11 January 2023
Abstract:
There is scientific support for the concept of a temperature set point that is, maintenance of an optimal temperature for the metabolic processes that life depends on Nervous activity in the preoptic-anterior hypothalamus of the brain triggers heat losing (sweating, etc.) or heat generating (shivering and muscle contraction, etc.) activities through stimulation of the autonomic nervous system.
The pre-optic anterior hypothalamus has been shown to contain warm sensitive, cool sensitive, and temperature insensitive neurons, to determine the body's temperature setpoint.
As the temperature that these neurons are exposed to rises above 37 °C (99 °F), the rate of electrical discharge of the warm-sensitive neurons increases progressively.
There is scientific support for the concept of a temperature set point that is, maintenance of an optimal temperature for the metabolic processes that life depends on Nervous activity in the preoptic-anterior hypothalamus of the brain triggers heat losing (sweating, etc.) or heat generating (shivering and muscle contraction, etc.) activities through stimulation of the autonomic nervous system.
The pre-optic anterior hypothalamus has been shown to contain warm sensitive, cool sensitive, and temperature insensitive neurons, to determine the body's temperature setpoint.
As the temperature that these neurons are exposed to rises above 37 °C (99 °F), the rate of electrical discharge of the warm-sensitive neurons increases progressively.
Keywords:
Hyperthermia; Temperature; HSP-70; Chemotherapy; Radiotherapy; Thermodox
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