Integrating multiple-unit pellet system and gastro-retentive drug delivery systems: A new era in oral drug delivery

Delivery Systems (GRDDS) are advanced pharmaceutical formulations designed to extend the residence time of drugs in the gastrointestinal (GI) tract, thereby enhancing the bioavailability of medications, particularly those with narrow absorption windows or significant first-pass metabolism. By improving drug solubility and absorption, GRDDS offers a strategic approach to optimizing therapeutic outcomes. Meanwhile, Multiple-Unit Pellet Systems (MUPS) utilize a multiparticulate design consisting of small, spherical pellets that enhance the pharmacokinetic and pharmacodynamic profiles of drugs, providing several advantages over traditional single-unit dosage forms. The integration of MUPS with GRDDS presents a novel formulation strategy aimed at harnessing the strengths of both systems. This combination not only aims to improve drug absorption but also to optimize therapeutic efficacy and enhance patient compliance. By leveraging the benefits of extended gastric retention and uniform drug distribution, this synergistic approach holds significant promise for advancing drug delivery technologies and improving clinical outcomes.