Kinetic and mechanistic study of oxidation of valine by pyridinium chlorochromate in aqueous DMF medium
Department of Chemistry, Govt. P. G. College Pratapgarh, 312605, Rajasthan, India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 14(03), 053–062.
Article DOI: 10.30574/wjbphs.2023.14.3.0247
Publication history:
Received on 28 April 2023; revised on 04 June 2023; accepted on 07 June 2023
Abstract:
Oxidative transformation of Valine by pyridinium chlorochromate in aqueous DMF medium, containing perchloric acid has been studied at 40 ℃. The rate of reaction was found to be of first order dependence on Oxidant, Valine, and H+ ion Concentration. The increase in the rate of reaction with increase in acidity indicates the involvement of a protonated chromium(VI) species in the rate-determining step. The product of oxidation has been identified as aldehyde. The rate of reaction decreased with increase in the polarity (dielectric constant of medium) of solvent, which indicates that there is involvement of an ion–dipole type of interaction in the rate-determining step. The activation parameters have been evaluated. On the basis of the experimental findings, a suitable mechanism and rate law has been proposed.
Keywords:
Kinetics; Oxidation; DMF (N, N-dimethylformamide); Valine; PCC (pyridinium chlorochromate)
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