Liposomal CoQ10: Turning Liquid Nanosystems into Stable Dosage Forms, an Approach of West Bengal Chemical Industries Limited.

The design and development of Lipoedge liposomal CoQ10 primarily depends on the composition of liposomes, physicochemical characteristics, interaction of CoQ10 with the liposomal structure, and their ability to demonstrate anti-oxidant levels post encapsulation. This is determined by the rearrangement of the phospholipids to embed CoQ10 molecules in the bilayer. Phospholipids present in the liposomes are dominated by a class of phospholipids called Phosphatidylcholine (PC). Depending on the method of liposome preparation, PC rearrange into a bilayer formation to encapsulate CoQ10. However, the process of assembling PC molecules to encapsulate CoQ10 stably remain to be a challenge due to the fragile nature of CoQ10. This article tries to address this gap by bridging the current understanding of the manufacturing parameters critical to ensure liposomal systems to stably encapsulate CoQ10 molecules and at the same time maintain its biological efficacy.