Medicated herbal chewing Gum to treat ulcers in mouth using Licorice and Capsicum annuum

This study explores the formulation and evaluation of herbal chewing gum containing extracts from Licorice (Glycyrrhiza glabra) and Capsicum Annuum, aimed at treating mouth ulcers. Licorice derived from roots. are known for their medicinal properties, it contains glycyrrhizin which is responsible for its sweet taste, including effects on sore throats, reduce inflammation and aid digestion. They contain various chemical compounds flavonoids such as such as liquirtin, rhamnoliquirilin, liquiritigenin, prenyllicoflavone A, glucoliquiritin apioside, metho-xyphaseolin, shinpterocarpin, shinflavanone, licopyranocoumarin, glisoflavone, licoarylcoumarin, coumarin-GU-12 and saponins namely glycyrrhizin flavonoids. While Capscicum annuum is recognized for its anti-oxidant, analgesic, insecticidal and anti ulcer properties, containing phytochemicals like carotenoids, flavonoids, capsaicinoids, phenolic compounds, vitamins and minerals. The preparation of the herbal chewing gum involved incorporating these extracts along with other necessary ingredients. Triethanolamine was added to adjust the pH to a suitable range (6.7-7.2) for oral mucosa compatibility.
The study emphasizes that chewing gums serve as mobile drug delivery systems, allowing for the incorporation of herbal medicines for treating mouth ulcers. The convenience of chewing gum enables self-medication without the need for water, with active substances being released during chewing. This method facilitates local treatment of mouth diseases and systemic delivery through absorption via the buccal mucosa the herbal chewing gum represents an effective drug delivery system.