Mercury retention after Panax ginseng treatment against mercuric chloride intoxication in hepato-haemato indices in albino rats
Department of Zoology, Experimental Laboratory, R. P. P. G. College Kamalganj, Farrukhabad (U.P.)-209724, Affiliated to CSJM University, Kanpur-282002 (U.P.), India.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(02), 345–349.
Article DOI: 10.30574/wjbphs.2023.13.2.0113
Publication history:
Received on 16 January 2023; revised on 25February 2023; accepted on 28 February 2023
Abstract:
Mercuric chloride was introduced per Os in albino rats (Rattus norvegicus) as per the LD50 (9.26 mg/kg b.w.). The assessment of mercuric chloride toxicity was done both after acute (0.926 mg/kg b.w.) and sub-acute (0.033 mg/kg b.w.) per Os treatment, while Panax ginseng was also introduced (10 mg/kg b.w.) per Os in the albino rats separately. Mercuric chloride treatment significantly increases mercury retention in liver and blood serum along with increase in liver weight, while Panax ginseng alone caused significant decrease in liver weight and mercury retention in liver and blood. Increase in mercury retention in blood serum and liver is due to the reactivity between –SH protein of blood serum and liver with oxidized form of mercury (Hg++), while decrease in Panax ginseng treatment is due to antioxidant activity of Panax ginseng the ginsenosides. Moreover, mercuric chloride followed by Panax ginseng and Panax ginseng followed by mercuric chloride treatment revealed significant modulation for raised mercury retention and liver weight towards normal level along with blood serum and liver changes. The results suggest a modulating role of Panax ginseng extract against raised mercury concentration in blood serum and liver under stress of mercuric chloride.
Keywords:
Mercuric chloride; Panax ginseng; Serum; Hepatic; Enzyme; Serum
Full text article in PDF:
Copyright information:
Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0