Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst

Sapkal Anjali; Kumar Rakesh; Purude Abhijeet

doi:10.30574/wjbphs.2024.17.1.0018

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Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst

Sapkal Anjali ^{1, *}, Kumar Rakesh ¹and Purude Abhijeet ²

1 Shri Jagdishprasad Jhabarmal Tibrewala University, Rajasthan, India.
2 Sinhgad College of Science, Maharashtra, India.

Review Article

World Journal of Biology Pharmacy and Health Sciences, 2024, 17(01), 114–116.

Article DOI: 10.30574/wjbphs.2024.17.1.0018

DOI url: https://doi.org/10.30574/wjbphs.2024.17.1.0018

Publication history

Received on 05 December 2023; revised on 17 January 2024; accepted on 20 January 2024

Abstract

In the present investigation synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione using microwave heating using proline catalyst. The synthesis of Hexa-Hydro-Quinolone derivatives, carried out by sequential in situ, Michael Addition, Cyclisation, and Aromatization. A new protocol for one step synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione with 98% yield.

Keywords

Microwave reactions; Michael addition reaction; Quinolone; Proline

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How to cite this article

Sapkal Anjali, Kumar Rakesh and Purude Abhijeet. Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst. World Journal of Biology Pharmacy and Health Sciences, 2024, 17(01), 114–116. Article DOI: https://doi.org/10.30574/wjbphs.2024.17.1.0018