Modern method of drug delivery across blood brain barrier
Vidyabharti College of Pharmacy, Amravati, Maharashtra, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2023, 14(02), 015–027.
Article DOI: 10.30574/wjbphs.2023.14.2.0198
Publication history:
Received on 18 March 2023; revised on 01 May 2023; accepted on 03 May 2023
Abstract:
Blood-brain barrier tightly regulates the flow of matter between the blood and brain, and it places restrictions on the amount of drugs that can enter the brain when taken systemically. As a consequence, brain diseases cannot be effecively treated with drugs. Treatment for various brain illnesses has not made any notable advancements recently. The BBB and achieving an adequate targeting capability for therapeutic molecules continue to be major obstacles. BBB supports the CNS's ability to maintain homeostasis. The BBB is better understood as a result of advancements in molecular biology, especially in various pathological situations. We'll examine contemporary techniques that can make use of these possibilities. Invasive and non-invasive approaches are the two primary types of drug distribution. To reduce risks, non-invasive means of drug delivery should be used to administer the medication. Utilization of nanotechnology in drug transport, receptor mediated targeting and transport and cell mediated drug transport will be covered in this review.
Keywords:
Blood brain barrier; Delivery technique; Nano-Technology; Receptor and cell mediated drug transport. Dendrimer; Invasive Non-Invasive
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0