Mortality predictors in emergency department adult patients with sepsis: A systematic review
1 Emergency Medicine, Head of Emergency Research Unit, Emergency Department, First Health Cluster, Riyadh, Saudi Arabia.
2 Saudi Board Emergency Medicine Resident, Emergency Department, Prince Sultan Military Medical City Riyadh, Kingdom of Saudi Arabia.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 19(03), 562–570.
Article DOI: 10.30574/wjbphs.2024.19.3.0680
Publication history:
Received on 11 August 2024; revised on 24 September 2024; accepted on 26 September 2024
Abstract:
Background: Sepsis was regarded as a major global public health concern; it continues to be associated with a high death rate despite advancements in contemporary treatment. This research aims to evaluate the predictive effect of clinical scoring systems and biomarkers for sepsis patients in ED.
Method: In accordance with PRISMA principles, we carried out this systematic review. We used the internet databases MEDLINE, Google Scholar, and EMBASE to conduct a thorough search of the literature. Articles written in English and released between 2015 and 2023 were involved in the search. Using predictors and ED, we first conducted a comprehensive search that included sepsis and infectious illnesses.
Result: A total of 3029 patients from 7 publications—3 cohort, 2 observational, and 2 case control studies—were included in this study. The study by Song et al. in 2019 had the highest fatality rate (46.6%), while the study by Duplessis et al. in 2018 had the lowest mortality rate (6.4%). SIRS criteria, qSOFA score, International Sepsis Conference 2001, and American College of Chest Physicians Guidelines are the diagnostic criteria that are employed. AUC varied from 33.7 (MMP9) to 0.89 (IL-6).
Conclusion: AUC was increased significantly when CSSs were combined with IgE, presepsin, IL-6 and PCT.
Keywords:
Sepsis; Emergency Department; Predictors; Mortality
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