Multifunctionality of statins as antimicrobials

Balbina J Plotkin 1, *, Alexis Borrelli 1, Matthew Erbst 1, Victoria Zheng 1, Monika I Konaklieva 2, Nicholas Schileru 1 and Ira M Sigar 1

1 Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA.
2 Department of Chemistry, American University, Washington, D.C., USA.
 
Review
World Journal of Biology Pharmacy and Health Sciences, 2022, 11(03), 001–012.
Article DOI: 10.30574/wjbphs.2022.11.3.0114
Publication history: 
Received on 23 July 2022; revised on 03 September 2022; accepted on 05 September 2022
 
Abstract: 
The potential of statins as antimicrobials has been recognized for more than a decade; unfortunately, minimal progress in exploring this promise. This mini review highlights the structure of statins and their relevance as antimicrobial co-drug. The current information on the inhibition mechanism of statins on bacterial, fungal, viral, and biofilms is also described.
 
Keywords: 
Fungi 1; Sar-CoV-2 2; Antimicrobial resistance 3; Lactone 4; Biofilm 5; Cholesterol 6
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0