1 Department of Chemistry (Biochemistry division), Faculty of Science, Port Said University, Egypt.
2 Department of Community, Environmental and Occupational Medicine. Ain Shams University.
3 Department of Chemistry, Faculty of Education, Ain Shams University, Egypt.
4 Department of Chemistry, Faculty of Science, Port Said University, Egypt.
5 Department of Biochemistry, Faculty of Science, Ain Shams University, Egypt.
World Journal of Biology Pharmacy and Health Sciences, 2025, 21(03), 636-641
Article DOI: 10.30574/wjbphs.2025.21.3.0307
Received on 10 February 2025; revised on 21 March 2025; accepted on 24 March 2025
Background: liver cancer has many complications; one of these complications is acute kidney injury. So, the treatment of hepatocellular carcinoma may enhance kidney functions. Cisplatin is one of the most successful chemotherapies used to treat hepatocellular carcinoma with bad side effects and to overcome these side effects; we hybrid it with Laurel nobilis leaves aqueous extract to treat hepatocellular carcinoma so the aim of this study is to determine the effect of the treatment of hepatocellular carcinoma with hybrid compound on kidney injury.
Methods: Blood Sample were collected from 36 adult Swiss albino rats. Alanine amino-transferase (ALT), aspartate amino- transferase (AST) and albumin (Alb) were assayed as good indicators for liver health and closely related to liver functions; also, creatinine and urea were also measured for kidney health.
Results: ALT, AST and albumin were significantly decreased in HCC rats treated with hybrid compound more than cisplatin treated animals and both of them were significant (P≤0.00) and so creatinine and urea were significantly decrease in hybrid compound more than cisplatin treated animals and both of them were significant (P≤0.001) compared to HCC group.
In Conclusion: The kidney functions increase with hepatocellular carcinoma and more enhancements in liver healthy the more enhancements in kidney function.
Hepatocellular Carcinoma; Acute Kidney Injury; Laurus nobilis L. Leaves; Chemotherapy; Hybrid Compound; Cisplatin
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Asmaa E. AbdElgalil, Shoman AE, Ibrahim A.M. El-Safty, Arafa A.M. Belal, Ekrami A. Hassan and ElSherbiny H. ElSayed. A new potential chemotherapy for the treatment of hepatocellular carcinoma and its relation to kidney function. World Journal of Biology Pharmacy and Health Sciences, 2025, 21(03), 636-641. Article DOI: https://doi.org/10.30574/wjbphs.2025.21.3.0307.