Novel titrimetric method for the determination of rosuvastatin in pure form
1 Department of pharmaceutical analysis, RVBRR women’s college of pharmacy, Barkatpura, Hyderabad- 500027, India.
2 Department of pharmaceutical chemistry, RBVRR women’s college of pharmacy, Barkatpura, Hyderabad- 500027, India.\
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(02), 001–004.
Article DOI: 10.30574/wjbphs.2023.13.2.0054
Publication history:
Received on 12 December 2022; revised on 26 January 2023; accepted on 28 January 2023
Abstract:
In this experiment assay of Rosuvastatin was performed by titrimetric method. The titration performed is a complexometric titration. The complexometric titration used is an easy, inexpensive volumetric titration method. This method is based on rection of calcium with a solution of disodium ethylenediaminotetraacetate (EDTA). Complex of calcium and EDTA is formed. Erichrome black Tis used as an indicator in this complexometric titration. At pH 12-13, Erichrome black T changes the color from pink to blue. The appearance blue color is determined to be the endpoint of this experiment. The titrations were carried out in triplicates and the average reading was taken to calculate the percentage assay. The percentage purity was found to be 103.05%
Keywords:
Complexometric Titration; Percentage Assay; Rosuvastatin; EDTA; Erichrome Black-T
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