Orally disintegrating tablet: A review
School of Pharmaceutical Science, Shri Guru Ram Rai University, Patel Nagar, Dehradun, 248001, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2022, 11(03), 018–025.
Article DOI: 10.30574/wjbphs.2022.11.3.0124
Publication history:
Received on 07 August 2022; revised on 15 September 2022; accepted on 17 September 2022
Abstract:
Orally dispersive tablets are solid dosage forms that dissolve in the mouth in within 10 to 30 seconds, enabling waterless ingestion. The tablet dissolves quickly due to its fast breakdown, which also causes the effects to start acting quickly. ODTs can help patients with a variety of conditions, including pediatrics, geriatrics, psychosis, dysphagia, bedridden discomfort, comatose patients, young patients with undeveloped muscular and nervous systems, patients with hand tremors, and patients who travel often. It provides high stability, precise dosage, efficient manufacture, and smaller packing; self-administration is allowed on long journeys because water is not required. ODTs are a cost-effective way to distribute drugs. When a medicine is absorbed through the buccal cavity, ODTs constitute a critical drug delivery method. Spray drying, sublimation, and other scientific procedures like freeze drying, moulding, and direct compression. . The availability of ODTs as over-the-counter drugs for the treatment of a range of illnesses is increasing. This article's objective is to go over the benefits, drawbacks, formulation difficulties, manufacturing methods, patented technologies, commercially available formulations, and evaluation checks of ODT. The word "Oro dispersible tablets" was created by the European Pharmacopoeia. This is an uncoated tablet that dissolves easily in the mouth for 3 minutes before being swallowed.
Keywords:
ODTs; Pills; Sublimation; Moulding; Direct compression; Improved bioavailability
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