Patient-centered care in precision medicine and end-of-life care in neuro-oncology: The role of nursing in enhancing quality of life and treatment outcomes

Central nervous system (CNS) tumors are a leading cause of cancer-related deaths in children. While advances in pediatric neuro-oncology have improved survival rates through surgery, radiation, and chemotherapy, these treatments often lead to long-term side effects—such as cognitive impairments, endocrine issues, and secondary cancers—that can significantly affect a child’s quality of life. Precision medicine offers hope by tailoring treatments based on the tumor’s molecular and genetic profile, targeting cancer cells while minimizing harm to healthy tissue. Equally important is patient-centered care (PCC), which addresses not only the clinical but also the emotional, psychosocial, and ethical needs of patients and families. Nurses play a pivotal role in integrating precision medicine and PCC, managing treatment-related symptoms, guiding shared decision-making, and supporting families—especially during end-of-life (EOL) care. Their role is critical as many patients experience cognitive and functional decline from the disease or its treatment.
This article explores the expanding role of nurses in pediatric neuro-oncology, particularly in EOL care, and emphasizes the need for a holistic approach that aligns with patients’ values and well-being. Future efforts should focus on strengthening interdisciplinary collaboration, improving communication, enhancing access to psychosocial support, and addressing ethical challenges. Continued education and support for nurses are essential to deliver personalised, compassionate care.