Pharmacological assessment of the aqueous extract of rose oil waste from Rosa x damascena Herrm cultivated in Georgia
1 Direction of Pharmacognosy and Botany, Faculty of Pharmacy, Tbilisi State Medical University, 33 Vazha Pshavela ave, Tbilisi, 0186, Georgia.
2 Department of Preclinical Pharmacological research, TSMU I.Kutateladze Institute of Pharmacochemistry, 36 P.Sarajishvili st, 0159, Tbilisi, Georgia.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2021, 07(01), 001-008.
Article DOI: 10.30574/wjbphs.2021.7.1.0069
Publication history:
Received on 29 May 2021; revised on 01 July 2021; accepted on 03 July 2021
Abstract:
Among Rosaceae family's most popular and important plants Rosa x damascena Herrm. holds one of the top places due to its centuries-long application in perfumery, cosmetics, aromatherapy and medicine. Despite this, the chemical and pharmacological study of different products obtained from R. damascena still does not lose its relevance. Currently, considerable attention is paid to the valorization of the waste from rose oil production in order to fully utilize valuable physiologically active constituents. The present study provides data on some pharmacological properties of the aqueous extract of rose oil waste from the R. damascena cultivated in Georgia. In particular, evaluation of gastro- and hepatoprotective activity of the aforesaid extract has been carried out in animal models and revealed its efficacy. The extract appeared to dose dependently stimulate leucopoiesis (up to 75%) and prevent ethanol-induced gastric injury (20-80%). As well, the extract ameliorated hepatoxic effects of carbon tetrachloride by 63%.
Keywords:
Rosa x damascena Herrm; Aqueous extract; Flavonoids; Gastroprotective; hepatoprotective
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