1 Department of Botany, Karnatak Science College, Dharwad-580003, Karnataka State, India.
2 Department of Applied Botany, Mangalore University, Mangalagangotri-574199, Mangalore, Karnataka State, India.
3 Miller Blvd, NW, Edmonton, Alberta, Canada.
4 Food Science and Nutrition, Department of Biosciences, Mangalore University, Mangalagangotri- 574199, Karnataka State, India.
5 Department of Zoology, Poornaprajna College, Autonomous, Udupi- 576101, Karnataka State, India.
6 Department of Chemistry, Environment and Food, Federal Institute of Amazonas, Campus Manaus Centro, Amazonas, Brazil- 69020-120.
World Journal of Biology Pharmacy and Health Sciences, 2025, 22(03), 329–336
Article DOI: 10.30574/wjbphs.2025.22.3.0582
Received on 29 March 2025; revised on 13 May 2025; accepted on 10 June 2025
Microplastics are now a global issue due to increased plastic production and use. Recently, various studies have been performed in response to the human health risk assessment. Due to their small size and wide distribution, microplastics are almost ubiquitous and can be easily ingested by organisms into the digestive system and then into the blood system. Microplastics have been reported as a new environmental pollutant due to their increased production and extremely low natural biodegradation in the ecosystem. Microplastic can accumulate within the body, increasing the risk of tis¬sue damage, fibrosis, and carcinogenesis. This risk is attributed to the induction of immune responses such as oxidative stress, apoptosis, and necrosis in the liver, intestines, brain, and other organs. Microplastic can lead to the proliferation of tumor cells and on the other hand causing damage to normal skin cells, indicating the potential harm caused by microplastics to skin tissues and cells. Recent study demonstrated for the first time the effect of microplastics on human breast and skin cancer. Bioplastics, which are both functionally similar to synthetic plastics and environmentally sustainable, are considered as promising new materials to address these problems.
Bioplastic; Microplastics; Carcinogenesis; Chronic inflammation; Oncogenesis; Immune regulation; Skin cancer; Synthetic polymers; Tumor
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Kiran P. Kolkar, Ravindra B. Malabadi, Raju K. Chalannavar, Divakar MS, Swathi, Kishore S. Karamchand and Antonia Neidilê Ribeiro Munhoz. Plastic pollution-Microplastics: Cancer related issues. World Journal of Biology Pharmacy and Health Sciences, 2025, 22(03), 329-336. Article DOI: https://doi.org/10.30574/wjbphs.2025.22.3.0582.