Protective potency of free radical scavengers against DEHP-induced testicular atrophy: A mini-review
1 Private Health Research Laboratory, 14-22 Shinkita-machi, Takamatsu-shi, Kagawa 760-0001, Japan.
2 Emeritus, Kagawa University, Japan.
Review
World Journal of Biology Pharmacy and Health Sciences, 2023, 15(02), 114–121.
Article DOI: 10.30574/wjbphs.2023.15.2.0345
Publication history:
Received on 28 June 2023; revised on 06 August 2023; accepted on 09 August 2023
Abstract:
Contamination with the plasticizer di(2-ethylhexyl) phthalate (DEHP) is widespread worldwide. DEHP has been found to have testicular toxicity in animal experiments, and is suspected to be reproductively toxic to mammals, including humans. Therefore, it is important to explore the effects of prophylaxis on DEHP-induced reproductive toxicity, such as testicular atrophy. The DEHP metabolite mono(2-ethylhexyl) phthalate (MEHP) is a potent oxidative stress factor and is thought to be an active toxicant involved in testicular damage. For this reason, free radical scavengers that protect the testis from inflammation and generation of reactive oxygen species are considered to be effective prophylactic agent. The authors discuss the efficacy of several free radical scavengers in preventing testicular atrophy. The efficacy of these free radical scavengers was revealed in a DEHP mixed diet exposure experiment. Examples include nicotinic acid, caffeine, ethanol, and the rare sugar D-allulose.
Keywords:
Di(2-ethylhexyl) phthalate (DEHP); Testicular atrophy; Free radical scavenger; D-allulose
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0