Review on Mucormycosis the uprising infection and post COVID effect
1 Department of Pharmaceutical Chemistry, Ideal College of Pharmacy and Research, Kalyan, India 421306.
2 Ideal College of Pharmacy and Research, Kalyan, India 421306.
Review
World Journal of Biology Pharmacy and Health Sciences, 2022, 10(03), 020–026.
Article DOI: 10.30574/wjbphs.2022.10.3.0066
Publication history:
Received on 12 March 2022; revised on 18 April 2022; accepted on 20 April 2022
Abstract:
Mucormycosis commonly called as Black Fungus is a fulminant angio-invasive infection that is caused by a distinctive group of fungi belonging to the genera of Class Zygomycetes and Taxonomic Order Mucorales, and is principally seen in immunosuppressed patients. It is an air-borne infection and primarily associated with upper and lower airways. It is a rare, infrequently and critically life-threatening fungal infection characterized by vascular invasion by hyphae and caused by the inhalation of its filamentous fungi, resulting in thrombosis, necrosis and infarction of tissue. The major risk factors that develop the infection include diabetic ketoacidosis, neutropenia, and protein-calorie malnutrition iron overload. Patients suffering from COVID-19 are more prone to have an infection due to low immunity power. Coronavirus disease causes an immunological disorder state and increases the risk of secondary infections like Mucormycosis. The mortality and morbidity rate caused by Mucormycosis has rapidly increased within the last decades, majorly in developing countries. Patients with Mucormycosis that endure surgical operation and who receive medical aid with IV Amphotericin B might have higher rates of survival. The work of the latest derivatives of azole within the treatment of Mucormycosis is unknown.
Keywords:
Mucormycosis; COVID-19; Fungal infection; Diabetic Ketoacidosis; Amphotericin
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