A review on spherical crystallization: A novel technique in the field of particle engineering
1 Student, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi, Virudhunagar district, Tamilnadu – 626001, India.
2 Associate professor, Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi, Virudhunagar district, Tamilnadu – 626001, India.
3 Professor and Head of the Department, Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi, Virudhunagar district, Tamilnadu – 626001, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2023, 13(01), 078-093.
Article DOI: 10.30574/wjbphs.2023.13.1.0281
Publication history:
Received on 20November 2022; revised on 03January 2023; accepted on 05January 2023
Abstract:
In the production of tablets, the direct compression method is mostly used. In comparison to the traditional wet granulation approach, this cannot be used with sensitive pharmaceuticals and also has a lot more processing limitations. Spherical agglomeration is a novel method for creating pharmaceutical dosage forms that are immediately compressible, the process of spherical agglomeration, which improves the powder's qualities such as particle size, shape, flow characteristics, solubility, and bioavailability of pharmaceutical medicinal ingredients, includes transforming tiny crystals into a spherical shape. The spherical crystallization was improved for use with hydrophilic polymers in order to improve the dissolution properties of pharmaceuticals that are poorly water-soluble. The flow characteristics, particle size analysis, compression, and dissolution behaviour of the spherical agglomerates were also improved. Wet spherical agglomeration (WSA) and the quasiemulsion solvent diffusion method (QESD) are the two most used methods for crystallizing spheres. Additionally, these approaches have two additions: the ammonia diffusion system (ADS) and crystallo-coagglomeration (CCA).The neutralization technique is another method used in this procedure. Any of the aforementioned methods can be employed simultaneously for both crystallization and agglomeration. The crystal physical characteristics, including their shape, polymorphism detection using x-ray powder diffraction (XRD), and thermodynamic characteristics using differential scanning calorimetry (DSC), were examined.
Keywords:
Spherical crystallization; Spherical agglomeration; Wet spherical agglomeration; Quasiemulsion solvent diffusion method; Ammonia diffusion system; Crystallo-coagglomeration; X-ray powder diffraction; Differential scanning calorimetry
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