A review on tablet binders as a pharmaceutical excipient
Department of Pharmaceutics, Yadavrao Tasgaonkar Institute of Pharmacy, University of Mumbai, Mumbai, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 17(03), 295–302.
Article DOI: 10.30574/wjbphs.2024.17.3.0142
Publication history:
Received on 11 February 2024; revised on 24 March 2024; accepted on 27 March 2024
Abstract:
The tablet formulation contains binders that increase the inter-particulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay tablet disintegration while disintegrant increase tablet disintegration. They play a vital role in making sure pellets or granules and tablets remain in shape until they reach their target by holding all ingredients (API and Excipients) together in any solid dosage form. Selecting the correct binder is critical to maintaining the integrity of the tablet. Natural binders such as various starches, Gums, mucus and dried fruits, among other things, have the ability to bind. Features such as Natural polymers, fillers, and disintegrants are also safe more economical than synthetic polymers.
Keywords:
Tablet; Binders; Excipients; Pharmaceutical
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0