Review topic: A detailed analysis of transdermal drug delivery system
Bhalchandra institute of pharmacy, Pune, Maharashtra, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(03), 292–300.
Article DOI: 10.30574/wjbphs.2024.20.3.0999
Publication history:
Received on 30 October 2024; revised on 05 December 2024; accepted on 07 December 2024
Abstract:
Transdermal drug delivery systems (TDDS) are a novel approach for administering medications through the skin, offering several advantages over conventional methods like oral or intravenous delivery. TDDS allow for controlled and consistent drug release, effectively bypassing the gastrointestinal tract and avoiding first-pass metabolism, which can enhance bioavailability and reduce systemic side effects. However, the skin's barrier properties present significant challenges for drug permeation, particularly for larger or hydrophilic molecules. To address these challenges, various methods have been developed, including chemical permeation enhancers, microneedles, iontophoresis, and sonophoresis, to facilitate drug delivery.
The typical components of TDDS include an active pharmaceutical ingredient, an adhesive matrix, a release liner, and a backing layer, each contributing to the controlled release and stability of the system. Despite these advancements, TDDS are primarily effective for small, lipophilic drugs, and issues such as skin irritation and limited permeation for larger molecules continue to be significant challenges. Recent innovations, such as the use of nanoparticles, 3D printing technology, and personalized delivery systems, show promise in overcoming these limitations. This review examines the principles, benefits, challenges, and recent developments in transdermal drug delivery systems, highlighting their potential applications in chronic disease management, hormone therapy, and vaccine delivery, as well as future directions for enhancing their efficacy and expanding their therapeutic range.
Keywords:
Patch; Topical administration; Systemic circulation; Transdermal drug delivery system
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0