Rice brain administration reduces malondialdehyde (MDA) levels in the heart of carbon tetrachloride-induced rats
1 Biochemistry and Molecular Biology Department, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, 10430, Indonesia.
2 Center of Hypoxia and Oxidative Stress Studies (CHOSS), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, 10430, Indonesia.
3 Medical Education Study Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, 10430, Indonesia.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 18(02), 403–409.
Article DOI: 10.30574/wjbphs.2024.18.2.0307
Publication history:
Received on 12 April 2024 revised on 20 May 2024; accepted on 22 May 2024
Abstract:
Excessive production of free radicals proven associated with disease progression of coronary heart disease. Rice bran oil has a high content of antioxidants such as tocopherol, tocotrienol, and γ-oryzanol. This study aimed to determine the effect of rice bran oil administration on malondialdehyde (MDA) level as an oxidative stress biomarker in the heart of carbon tetrachloride (CCl4)-induced rats. Thirty stored rat heart tissue samples that were divided into six groups, consisted of untreated control group, CCl4-treated group (CCl), rice bran oil-treated before CCl4 induction groups with rice bran oil dosage of 0.5 ml (B1+CCl) and 1.5 ml (B2+CCl), and rice bran oil-treated after CCl4 induction groups with rice bran oil dosage of 0.5 ml (CCl+B1) and 1.5 ml (CCl+B2), were measured for their MDA levels using Wills modified method. The highest heart’s MDA levels were obtained in the group that only received carbon tetrachloride. The lowest heart’s MDA levels were found in the group given 1.5 ml of rice bran oil before being given carbon tetrachloride. Heart MDA levels in all groups given rice bran either before or after administration of carbon tetrachloride were lower than those in the group given only carbon tetrachloride. The lowest heart MDA found in the group that was administered by 1.5 ml/day of rice bran oil before carbon tetrachloride induction.
Keywords:
Malondialdehyde; Heart; Carbon Tetrachloride; Rice Bran
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